Table 2.
Age-adjusted ORs and 95% CIs for CYP19A1 haplotypes and risk of breast cancer and fibrocystic conditions, by proliferative status
| Breast cancer | Fibrocystic Breast Conditions | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Overall | With non-proliferative fibrocystic conditions |
With proliferative fibrocystic conditions |
Control | Overall | Non-proliferative | Proliferative | ||||||||
| Haplotype | Freq. | Freq.* | OR (95% CI) | Freq.* | OR (95% CI) | Freq.* | OR (95% CI) | Freq. | Freq.* | OR (95% CI) | Freq.* | OR (95% CI) | Freq.* | OR (95% CI) | |
| Block 1 (rs1870049, rs1004982) | |||||||||||||||
| 00 | TT | 0.67 | 0.67 | 1.00 (ref) | 0.68 | 1.00 (ref) | 0.60 | 1.00 (ref) | 0.67 | 0.64 | 1.00 (ref) | 0.66 | 1.00 (ref) | 0.65 | 1.00 (ref) |
| 11 | CC | 0.20 | 0.21 | 1.07 (0.89,1.28) | 0.21 | 1.02 (0.73,1.44) | 0.24 | 1.36 (0.97,1.91) | 0.20 | 0.22 | 1.13 (0.92,1.38) | 0.20 | 1.00 (0.73,1.36) | 0.19 | 0.99 (0.74,1.34) |
| 01 | TC | 0.12 | 0.11 | 0.94 (0.74,1.18) | 0.10 | 0.84 (0.53,1.31) | 0.16 | 1.45 (0.98,2.15) | 0.12 | 0.12 | 1.12 (0.87,1.44) | 0.12 | 1.11 (0.77,1.61) | 0.14 | 1.26 (0.91,1.75) |
| 10 | CT | 0.01 | 0.01 | 0.97 (0.47,2.02) | 0.01 | 1.21 (0.39,3.81) | 0.01 | 0.57 (0.08,3.91) | 0.01 | 0.01 | 1.37 (0.68,2.78) | 0.01 | 1.32 (0.50,3.47) | 0.01 | 1.22 (0.45,3.34) |
| Block 2 (rs28566535, rs93636) | |||||||||||||||
| 00 | AC | 0.66 | 0.64 | 1.00 (ref) | 0.66 | 1.00 (ref) | 0.57 | 1.00 (ref) | 0.66 | 0.65 | 1.00 (ref) | 0.66 | 1.00 (ref) | 0.66 | 1.00 (ref) |
| 11 | CT | 0.31 | 0.31 | 1.02 (0.87,1.20) | 0.30 | 0.98 (0.73,1.31) | 0.36 | 1.35 (1.01,1.81) | 0.31 | 0.32 | 1.05 (0.89,1.25) | 0.30 | 0.99 (0.76,1.28) | 0.31 | 1.01 (0.79,1.29) |
| 01 | AT | 0.02 | 0.03 | 1.36 (0.88,2.12) | 0.02 | 0.99 (0.41,2.37) | 0.03 | 1.64 (0.78,3.47) | 0.02 | 0.02 | 0.86 (0.48,1.56) | 0.02 | 1.09 (0.48,2.46) | 0.01 | 0.49 (0.15,1.53) |
| 10 | CC | 0.01 | 0.02 | 1.44 (0.85,2.43) | 0.02 | 1.66 (0.70,3.93) | 0.04 | 2.81 (1.37,5.77) | 0.01 | 0.02 | 1.10 (0.60,1.99) | 0.02 | 1.21 (0.52,2.80) | 0.01 | 0.89 (0.35,2.26) |
| Block 3 (rs11636639) | |||||||||||||||
| 0 | G | 0.53 | 0.53 | 1.00 (ref) | 0.51 | 1.00 (ref) | 0.53 | 1.00 (ref) | 0.53 | 0.52 | 1.00 (ref) | 0.51 | 1.00 (ref) | 0.54 | 1.00 (ref) |
| 1 | T | 0.47 | 0.47 | 1.01 (0.87,1.17) | 0.49 | 1.12 (0.85,1.46) | 0.47 | 1.02 (0.77,1.34) | 0.47 | 0.48 | 0.98 (0.83,1.16) | 0.49 | 1.03 (0.80,1.32) | 0.46 | 0.94 (0.75,1.18) |
| Block 4 (rs767199, rs4775936, rs11575899 (ins-del), rs10046, rs4646) | |||||||||||||||
| 00000 | ATITG | 0.41 | 0.39 | 1.00 (ref) | 0.41 | 1.00 (ref) | 0.35 | 1.00 (ref) | 0.41 | 0.40 | 1.00 (ref) | 0.42 | 1.00 (ref) | 0.40 | 1.00 (ref) |
| 11111 | CGDCT | 0.24 | 0.25 | 1.09 (0.90,1.32) | 0.23 | 1.01 (0.71,1.44) | 0.23 | 1.16 (0.79,1.70) | 0.24 | 0.24 | 1.00 (0.81,1.24) | 0.26 | 1.04 (0.76,1.42) | 0.25 | 1.09 (0.81,1.46) |
| 11010 | GCICG | 0.13 | 0.14 | 1.12 (0.89,1.42) | 0.14 | 1.07 (0.70,1.62) | 0.13 | 1.20 (0.76,1.90) | 0.13 | 0.14 | 1.08 (0.83,1.39) | 0.14 | 1.04 (0.71,1.53) | 0.13 | 1.07 (0.74,1.55) |
| 11000 | GCITG | 0.08 | 0.08 | 0.97 (0.73,1.30) | 0.07 | 0.87 (0.50,1.51) | 0.12 | 1.72 (1.06,2.80) | 0.08 | 0.10 | 1.33 (0.98,1.81) | 0.10 | 1.32 (0.84,2.07) | 0.10 | 1.38 (0.90,2.11) |
| 01000 | ACITG | 0.03 | 0.04 | 1.25 (0.84,1.86) | 0.06 | 1.87 (1.07,3.26) | 0.03 | 1.37 (0.64,2.93) | 0.02 | 0.02 | 0.68 (0.41,1.15) | 0.02 | 0.70 (0.32,1.54) | 0.01 | 0.21 (0.05,0.86) |
| 11011 | GCICT | 0.03 | 0.03 | 1.33 (0.85,2.08) | 0.04 | 1.54 (0.73,3.26) | 0.03 | 1.68 (0.74,3.85) | 0.03 | 0.02 | 0.85 (0.47,1.53) | 0.01 | 0.27 (0.06,1.20) | 0.03 | 1.13 (0.53,2.39) |
| 10000 | GTITG | 0.02 | 0.02 | 1.12 (0.69,1.80) | 0.01 | 0.58 (0.17,1.95) | 0.01 | 0.79 (0.25,2.46) | 0.02 | 0.02 | 0.86 (0.48,1.56) | 0.01 | 0.61 (0.20,1.88) | 0.02 | 0.86 (0.37,2.01) |
| 11100 | GCDTG | 0.01 | 0.02 | 1.56 (0.86,2.80) | 0.01 | 1.66 (0.60,4.57) | 0.04 | 3.54 (1.59,7.89) | 0.01 | 0.01 | 0.96 (0.45,2.02) | 0.01 | 0.88 (0.28,2.74) | 0.01 | 0.40 (0.09,1.71) |
| 10111 | CTDCT | 0.01 | 0.01 | 1.03 (0.51,2.09) | 0.01 | 0.65 (0.16,2.70) | 0.01 | 1.02 (0.38,2.77) | |||||||
| Others | 0.04 | 0.04 | 0.02 | 0.05 | 0.04 | 0.03 | 0.02 | 0.04 | |||||||
*
All p-values of the global score test were greater than 0.05, except for block 2 when restricted to breast cancer cases with concurrent proliferative fibrocystic conditions (p=0.007).