Table 3.
Age-adjusted ORs and 95% CIs for CYP19A1 genotypes and risk of breast cancer with proliferative fibrocystic conditions, by menopausal status and BMI
| By menopausal status | By BMI | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Breast cancer cases with proliferative fibrocystic conditions |
Controls | Breast cancer cases with proliferative fibrocystic conditions |
|||||||||||||
| Pre | Post | Premenopausal | Postmenopausal | <23 | 23+ | <23 kg/m2 | 23+ kg/m2 | |||||||||
| n | n | n | OR | 95% CI | n | OR | 95% CI | n | n | n | OR | 95% CI | n | OR | 95% CI | |
| Block 1 | ||||||||||||||||
| rs1870049 | ||||||||||||||||
| TT | 333 | 215 | 41 | 1.00 | (ref) | 26 | 1.00 | (ref) | 242 | 306 | 25 | 1.00 | (ref) | 41 | 1.00 | (ref) |
| CT | 166 | 126 | 21 | 1.04 | (0.60–1.82) | 20 | 1.30 | (0.70–2.42) | 127 | 165 | 13 | 0.98 | (0.48–1.99) | 28 | 1.26 | (0.75–2.12) |
| CC | 29 | 9 | 6 | 1.64 | (0.64–4.19) | 2 | 1.90 | (0.39–9.34) | 16 | 22 | 4 | 2.42 | (0.75–7.82) | 4 | 1.41 | (0.46–4.33) |
| rs1870049 | ||||||||||||||||
| TT | 256 | 154 | 30 | 1.00 | (ref) | 14 | 1.00 | (ref) | 186 | 224 | 21 | 1.00 | (ref) | 22 | 1.00 | (ref) |
| CT | 210 | 161 | 25 | 1.03 | (0.58–1.80) | 23 | 1.54 | (0.76–3.10) | 161 | 210 | 11 | 0.59 | (0.28–1.27) | 37 | 1.78 | (1.01–3.11) |
| CC | 59 | 31 | 11 | 1.53 | (0.72–3.25) | 10 | 3.66 | (1.48–9.02) | 35 | 55 | 9 | 2.29 | (0.97–5.42) | 12 | 2.23 | (1.04–4.78) |
| Block 2 | ||||||||||||||||
| rs28566535 | ||||||||||||||||
| AA | 245 | 159 | 28 | 1.00 | (ref) | 17 | 1.00 | (ref) | 187 | 217 | 20 | 1.00 | (ref) | 25 | 1.00 | (ref) |
| AC | 214 | 156 | 29 | 1.16 | (0.67–2.02) | 16 | 0.93 | (0.46–1.92) | 160 | 210 | 14 | 0.81 | (0.40–1.66) | 30 | 1.23 | (0.70–2.17) |
| CC | 63 | 31 | 10 | 1.33 | (0.61–2.89) | 13 | 4.03 | (1.77–9.18) | 33 | 61 | 8 | 2.27 | (0.92–5.59) | 15 | 2.15 | (1.07–4.33) |
| rs936306 | ||||||||||||||||
| CC | 250 | 155 | 29 | 1.00 | (ref) | 20 | 1.00 | (ref) | 185 | 220 | 20 | 1.00 | (ref) | 29 | 1.00 | (ref) |
| CT | 212 | 156 | 28 | 1.11 | (0.64–1.93) | 14 | 0.68 | (0.33–1.39) | 161 | 207 | 15 | 0.86 | (0.42–1.73) | 26 | 0.94 | (0.54–1.66) |
| TT | 65 | 37 | 10 | 1.27 | (0.59–2.75) | 14 | 3.00 | (1.38–6.51) | 38 | 64 | 7 | 1.71 | (0.67–4.33) | 17 | 2.01 | (1.04–3.89) |
| Block 3 | ||||||||||||||||
| rs11636639 | ||||||||||||||||
| GG | 145 | 99 | 18 | 1.00 | (ref) | 13 | 1.00 | (ref) | 102 | 142 | 13 | 1.00 | (ref) | 17 | 1.00 | (ref) |
| GT | 243 | 167 | 33 | 1.15 | (0.62–2.14) | 26 | 1.18 | (0.58–2.40) | 184 | 226 | 20 | 0.86 | (0.41–1.82) | 39 | 1.42 | (0.77–2.61) |
| TT | 130 | 68 | 16 | 1.00 | (0.49–2.04) | 9 | 1.08 | (0.43–2.69) | 91 | 107 | 9 | 0.79 | (0.32–1.95) | 16 | 1.27 | (0.61–2.63) |
| Block 4 | ||||||||||||||||
| rs767199 | ||||||||||||||||
| AA | 116 | 69 | 12 | 1.00 | (ref) | 5 | 1.00 | (ref) | 80 | 105 | 8 | 1.00 | (ref) | 9 | 1.00 | (ref) |
| AG | 254 | 184 | 36 | 1.44 | (0.72–2.89) | 23 | 1.69 | (0.62–4.63) | 198 | 240 | 24 | 1.21 | (0.52–2.81) | 35 | 1.68 | (0.78–3.62) |
| GG | 158 | 97 | 19 | 1.16 | (0.54–2.49) | 19 | 2.65 | (0.94–7.46) | 107 | 148 | 10 | 0.93 | (0.35–2.47) | 27 | 2.12 | (0.96–4.69) |
| rs4775936 | ||||||||||||||||
| TT | 110 | 64 | 12 | 1.00 | (ref) | 4 | 1.00 | (ref) | 73 | 101 | 6 | 1.00 | (ref) | 10 | 1.00 | (ref) |
| CT | 262 | 197 | 31 | 1.10 | (0.55–2.23) | 24 | 1.91 | (0.64–5.73) | 205 | 254 | 23 | 1.37 | (0.54–3.51) | 32 | 1.23 | (0.58–2.60) |
| CC | 155 | 88 | 24 | 1.42 | (0.68–2.97) | 20 | 3.57 | (1.16–10.97) | 106 | 137 | 13 | 1.50 | (0.54–4.13) | 30 | 2.17 | (1.01–4.65) |
| rs11575899 | ||||||||||||||||
| INS/INS | 272 | 181 | 33 | 1.00 | (ref) | 24 | 1.00 | (ref) | 194 | 259 | 19 | 1.00 | (ref) | 38 | 1.00 | (ref) |
| INS/DEL | 211 | 147 | 25 | 0.98 | (0.57–1.71) | 20 | 1.05 | (0.56–1.99) | 158 | 200 | 17 | 1.10 | (0.55–2.18) | 27 | 0.93 | (0.55–1.57) |
| DEL/DEL | 45 | 20 | 9 | 1.69 | (0.76–3.78) | 3 | 1.13 | (0.31–4.10) | 31 | 34 | 5 | 1.65 | (0.57–4.74) | 7 | 1.43 | (0.59–3.46) |
| rs10046 | ||||||||||||||||
| TT | 168 | 109 | 21 | 1.00 | (ref) | 9 | 1.00 | (ref) | 120 | 157 | 10 | 1.00 | (ref) | 20 | 1.00 | (ref) |
| CT | 253 | 183 | 38 | 1.25 | (0.70–2.21) | 29 | 1.89 | (0.86–4.16) | 190 | 246 | 28 | 1.77 | (0.83–3.77) | 39 | 1.23 | (0.69–2.18) |
| CC | 107 | 56 | 8 | 0.60 | (0.25–1.40) | 9 | 1.96 | (0.74–5.22) | 73 | 90 | 3 | 0.49 | (0.13–1.85) | 13 | 1.14 | (0.54–2.40) |
| rs4646 | ||||||||||||||||
| GG | 264 | 177 | 35 | 1.00 | (ref) | 21 | 1.00 | (ref) | 183 | 258 | 20 | 1.00 | (ref) | 36 | 1.00 | (ref) |
| GT | 210 | 148 | 27 | 0.97 | (0.57–1.66) | 23 | 1.33 | (0.71–2.51) | 164 | 194 | 20 | 1.12 | (0.58–2.15) | 29 | 1.07 | (0.64–1.81) |
| TT | 54 | 23 | 5 | 0.71 | (0.27–1.91) | 3 | 1.09 | (0.30–3.94) | 36 | 41 | 1 | 0.25 | (0.03–1.95) | 7 | 1.25 | (0.52–2.99) |