Table 4.
Age-adjusted ORs and 95% CIs for CYP19A1 haplotypes and risk of breast cancer with proliferative fibrocystic conditions, by menopausal status and BMI
| Breast cancer with proliferative fibrocystic conditions | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Premenopausal | Postmenopausal | BMI <23.0 kg/m2 | BMI 23.0+ kg/m2 | ||||||
| Haplotype | Freq.* | OR (95%CI) | Freq.* | OR (95%CI) | Freq.* | OR (95%CI) | Freq.* | OR (95%CI) | |
| Block 1 (rs1870049, rs1004982) | |||||||||
| 00 | TT | 0.64 | 1.00 (ref) | 0.53 | 1.00 (ref) | 0.64 | 1.00 (ref) | 0.57 | 1.00 (ref) |
| 11 | CC | 0.24 | 1.23 (0.82,1.87) | 0.24 | 1.56 (0.87,2.80) | 0.25 | 1.36 (0.80,2.32) | 0.24 | 1.38 (0.89,2.13) |
| 01 | TC | 0.11 | 1.06 (0.60,1.85) | 0.22 | 2.15 (1.21,3.84) | 0.11 | 1.08 (0.53,2.22) | 0.19 | 1.70 (1.05,2.75) |
| 10 | CT | -- | 0.01 | 1.34 (0.15,11.92) | -- | 0.00 | |||
| Block 2 (rs28566535, rs93636) | |||||||||
| 00 | AC | 0.60 | 1.00 (ref) | 0.52 | 1.00 (ref) | 0.62 | 1.00 (ref) | 0.54 | 1.00 (ref) |
| 11 | CT | 0.33 | 1.15 (0.78,1.68) | 0.40 | 1.69 (1.07,2.66) | 0.32 | 1.24 (0.76,2.02) | 0.38 | 1.39 (0.97,2.00) |
| 01 | AT | 0.03 | 1.67 (0.63,4.45) | 0.03 | 1.57 (0.49,5.00) | 0.02 | 1.26 (0.32,4.88) | 0.04 | 1.91 (0.77,4.73) |
| 10 | CC | 0.04 | 2.04 (0.82,5.06) | 0.05 | 5.11 (1.41,18.51) | 0.04 | 3.17 (0.89,11.32) | 0.04 | 2.62 (1.09,6.28) |
| Block 3 (rs11636639) | |||||||||
| 0 | G | 0.21 | 1.00 (ref) | 0.54 | 1.00 (ref) | 0.55 | 1.00 (ref) | 0.51 | 1.00 (ref) |
| 1 | T | 0.49 | 1.00 (0.70,1.44) | 0.46 | 1.05 (0.68,1.62) | 0.45 | 0.89 (0.56,1.40) | 0.49 | 1.14 (0.80,1.61) |
| Block 4 (rs767199, rs4775936, rs11575899 (ins-del), rs10046, rs4646) | |||||||||
| 00000 | ATITG | 0.39 | 1.00 (ref) | 0.30 | 1.00 (ref) | 0.42 | 1.00 (ref) | 0.32 | 1.00 (ref) |
| 11111 | CGDCT | 0.24 | 1.05 (0.65,1.68) | 0.20 | 1.26 (0.68,2.34) | 0.23 | 0.83 (0.44,1.59) | 0.23 | 1.31 (0.80,2.14) |
| 11010 | GCICG | 0.12 | 0.87 (0.47,1.61) | 0.17 | 1.75 (0.88,3.48) | 0.12 | 1.06 (0.49,2.33) | 0.13 | 1.26 (0.70,2.26) |
| 11000 | GCITG | 0.08 | 1.08 (0.52,2.23) | 0.18 | 2.66 (1.34,5.30) | 0.09 | 0.88 (0.35,2.22) | 0.15 | 2.62 (1.43,4.80) |
| 01000 | ACITG | 0.04 | 1.33 (0.59,3.02) | -- | 0.02 | 0.77 (0.17,3.45) | 0.03 | 1.86 (0.71,4.86) | |
| 11011 | GCICT | 0.03 | 0.85 (0.24,2.97) | 0.05 | 3.45 (1.09,11.46) | 0.03 | 0.96 (0.20,4.60) | 0.04 | 2.22 (0.79,6.19) |
| 10000 | GTITG | 0.02 | 0.76 (0.19,2.04) | 0.01 | 0.67 (0.09,5.04) | -- | 0.02 | 1.33 (0.41,4.34) | |
| 11100 | GCDTG | 0.06 | 4.24 (1.70,10.58) | 0.01 | 1.39 (0.20,9.63) | 0.06 | 11.19 (2.81,44.50) | 0.03 | 1.96 (0.65,5.89) |
| Others | 0.02 | 0.08 | 0.03 | 0.05 | |||||
*
Global score test p-values for premenopausal women: 0.60 (block 1), 0.33 (block 2), 0.10 (block 4)
Global score test p-values for postmenopausal women: 0.048 (block 1), 0.009 (block 2), 0.04 (block 4)
Global score test p-values for BMI <23 kg/m2: 0.57 (block 1), 0.26 (block 2), 0.02 (block 4)
Global score test p-values for BMI 23.0+ kg/m2: 0.12 (block 1), 0.043 (block 2), 0.07 (block 4)