Figure 3. C. jejuni induces rapid and progressive severe colonic inflammation in IL-10−/−; NF-κBEGFP mice.
Gnotobiotic IL-10−/−; NF-κBEGFP mice and control IL-10wt/wt; NF-κBEGFP mice were associated with C. jejuni by oral gavage (108 cfu/mouse). Inflammation was evaluated macroscopically in vivo using a murine miniature endoscope in IL-10wt/wt; NF-κBEGFP control mice (Fig. 2A, n = 13) and IL-10−/−; NF-κBEGFP mice on day 5 and 14 (Fig. 2B, n = 12). The data are representative for two additional experiments.