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. 2009 Oct 21;4(10):e7189. doi: 10.1371/journal.pone.0007189

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Siso-Nadal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a A bifurcation diagram for calcium as a function of activated PLC when activated AC is at 0.17 M. Symbols are the same as Fig. 2. PD indicates a period-doubling bifurcation. Example time courses of calcium and cAMP are shown when activated PLC is at 0.2 M, 0.28 M, 0.31 M, and 0.36 M. Bursting oscillations appear for intermediate activated PLC concentrations. The amplitude of the oscillations increases and decreases as activated PLC increases, and oscillations gradually disappear. b The frequency of the cAMP and calcium oscillations as a function of both activated AC and PLC concentrations. c The amplitude of the calcium oscillations. d The amplitude of the cAMP oscillations.

Inline graphic — a A bifurcation diagram for calcium as a function of activated PLC when activated AC is at 0.17 M. Symbols are the same as Fig. 2. PD indicates a period-doubling bifurcation. Example time courses of calcium and cAMP are shown when activated PLC is at 0.2 M, 0.28 M, 0.31 M, and 0.36 M. Bursting oscillations appear for intermediate activated PLC concentrations. The amplitude of the oscillations increases and decreases as activated PLC increases, and oscillations gradually disappear. b The frequency of the cAMP and calcium oscillations as a function of both activated AC and PLC concentrations. c The amplitude of the calcium oscillations. d The amplitude of the cAMP oscillations.