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. 2009 Jul 13;37(16):5353–5364. doi: 10.1093/nar/gkp582

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — RHPS4 induces telomere aberrations. BJ-HELT fibroblasts were treated with 0.5 μM RHPS4 for 96 h and hybridized successively with a telomeric PNA probe (in red) and then counterstained with Hoechst (blue). Histograms show the mean of damaged telomeres per cell in metaphase spreads. ***t-test P-value <0.0001. Representative images of the different telomere aberrations are presented at the bottom.