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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Arthritis Rheum. 2008 Nov;58(11):3541–3549. doi: 10.1002/art.23961

Figure 3. Granulopoiesis signature in the bone marrow as a marker for SLE activity.

Figure 3

Nine genes selected a priori were used to investigate associations between a granulopoeisis signature and SLEDAI. These genes resulted in a statistically significant model of SLEDAI. (A) A numerical score was calculated by using the normalized expression levels of 9 granulopoiesis-related genes that comprise the granulopoiesis signature. Linear regression analysis demonstrates a correlation between granulopoiesis score and SLEDAI (r = 0.33) in the peripheral blood of patient subset that have also provided BM. (B) Granulopoiesis signature of the patients analyzed on Panel A, correlates stronger with SLEDAI in the bone marrow (r = 0.55, p = 0.013). C. The granulopoiesis score from bone marrow was higher in the active group of SLE patients vs the inactive (p =0.004)