Skip to main content
. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Am J Transplant. 2009 Jul 28;9(10):2251–2261. doi: 10.1111/j.1600-6143.2009.02786.x

Figure 6. Wild-type Tregs restore long-term bm12 cardiac allograft survival in B6.CCR5-/- recipients.

Figure 6

1.2 × 106 flow sort purified CD4+CD25- or CD4+CD25+T cells from naïve wild-type or CCR5-/- B6 mice were transferred to B6.CCR5-/-recipients of bm12 heart allografts one day prior to transplant and graft survival was monitored daily by palpation. Transfer of wild-type Tregs (CD4+CD25+) to B6.CCR5-/- recipients of bm12 heart allografts prolonged survival of 60% of the grafts (3/5) to greater than 60 days post-transplant, whereas transfer of CD4+CD25- T cells or CCR5-/- CD4+CD25+ Tregs did not restore graft survival in CCR5-deficient recipients. Log-rank testing was used to determine significance as shown. * p > 0.05 vs. bm12 to CCR5-/- plus wild-type CD4+CD25+ T cells. ## p < 0.05 vs. CCR5-/- Treg transfer group.