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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Curr Opin Microbiol. 2009 Aug;12(4):460–466. doi: 10.1016/j.mib.2009.06.016

Figure 2. Weakening HIV-1 Tat positive feedback biases HIV-1 towards latency and limits reactivation.

Figure 2

(A) Schematics of full-length HIV-1 with nef replaced by a gfp reporter (blue) and the SirT1 over expression effect (red). (B) SirT1 over expression deacetylase Tat and reduces positive-feedback strength (red) as evidenced from gene expression noise analysis. (C) SirT1 over-expressing cells have a higher probability of entering latency and show decreased latent reactivation [26].