Table 4.
Genes that possess SHR-specific alleles that manifest allelic expression are contained within haplotype blocks shared by SHR lines and distinct from WKY lines. This is demonstrated by examining the distribution of microsatellite marker alleles from the Allele Characterization Project of the Rat Genome Project. The table indicates the microsatellite allele sizes in each locus surrounding the 5 genes (outlined by boxing) that we have identified as possessing SHR allele-specific expression. In each case, the allelic expression genes are outlined in a block (shaded) in which both microsatellite alleles and alleles of the genes identified in this study share the same pattern of distribution between SHR and WKY. Each block is accompanied by the contiguous three markers up and downstream of the block (unshaded) and is defined by a shift in the immediately adjacent marker pattern so that the pattern of allele sharing among SHR, but not by WKY, is broken.
| RGD NAME | Chromosome | Position | SHRSP/Riv | SHR/OlaHsd | WKY/OlaHsd |
|---|---|---|---|---|---|
| D3Rat50 | 3 | 62,184,492 | 203 | 203 | 209 |
| D3Rat191 | 3 | 62,454,399 | 168 | 168 | 170 |
| D3Rat131 | 3 | 65,405,012 | 211 | 211 | 211 |
| D3Rat51 | 3 | 66,171,893 | 172 | 172 | 176 |
| D3Rat234 | 3 | 68,184,506 | 168 | 168 | 166 |
| D3Rat277 | 3 | 68,713,283 | 256 | 256 | 250 |
| Ptprj | 3 | 74,693,135 | S | S | W |
| D3Rat49 | 3 | 74,807,506 | 144 | 144 | 146 |
| D3Rat48 | 3 | 76,428,105 | 156 | 156 | 158 |
| D3Rat82 | 3 | 76,517,091 | 177 | 177 | 175 |
| D3Rat98 | 3 | 76,765,437 | 126 | 126 | 126 |
| D3Rat47 | 3 | 76,914,407 | 221 | 221 | 227 |
| D3Rat80 | 3 | 77,307,735 | 156 | 156 | 144 |
| D7Rat117 | 7 | 136,702,354 | 130 | 130 | 106 |
| D7Rat3 | 7 | 137,480,818 | 129 | 129 | 127 |
| D7Rat2 | 7 | 137,833,770 | 264 | 268 | 266 |
| D7Mit9 | 7 | 137,915,237 | 274 | 274 | 278 |
| D7Rat116 | 7 | 139,122,462 | 150 | 150 | 162 |
| Ela1 | 7 | 139,515,742 | S | S | W |
| D7Rat101 | 7 | 140,922,838 | 137 | 137 | 140 |
| D7Rat93 | 7 | 140,980,442 | 120 | 120 | 116 |
| D7Rat105 | 7 | 141,253,100 | 152 | 152 | 154 |
| D7Rat114 | 7 | 141,296,882 | 208 | 208 | 204 |
| D7Rat80 | 7 | 141,377,964 | 224 | 224 | 224 |
| D7Mit20 | 7 | 141,447,270 | 118 | 118 | 118 |
| D7Rat1 | 7 | 142,132,345 | 212 | 212 | 216 |
| D8Rat57 | 8 | 9,421,671 | 170 | 170 | 170 |
| D8Mit9 | 8 | 9,581,030 | 157 | 157 | 157 |
| D8Mit6 | 8 | 9,581,132 | 243 | 243 | 243 |
| AA866432 | 8 | 11,151,250 | S | S | W |
| D8Rat170 | 8 | 12,964,557 | 189 | 189 | 200 |
| D8Rat110 | 8 | 13,288,779 | 204 | 204 | 198 |
| D8Rat105 | 8 | 19,782,791 | 129 | 129 | 137 |
| D8Rat53 | 8 | 19,815,642 | 150 | 150 | 158 |
| D8Rat165 | 8 | 20,717,106 | 192 | 192 | 222 |
| D8Rat52 | 8 | 20,962,778 | 221 | 221 | 213 |
| D8Rat190 | 8 | 28,124,139 | 124 | 124 | 126 |
| D8Rat51 | 8 | 29,565,712 | 152 | 152 | 163 |
| D8Rat50 | 8 | 30,725,320 | 168 | 168 | 168 |
| D8Rat162 | 8 | 30,887,344 | 246 | 246 | 252 |
| D8Rat163 | 8 | 31,517,290 | 183 | 183 | 183 |
| D8Rat28 | 8 | 67,261,781 | 152 | 152 | 152 |
| D8Rat144 | 8 | 68,275,463 | 203 | 203 | 203 |
| D8Rat34 | 8 | 68,808,874 | 156 | 156 | 156 |
| D5Rat179 | 8 | 69,243,864 | 264 | 264 | 236 |
| D8Rat147 | 8 | 69,433,881 | 180 | 180 | 170 |
| D8Rat62 | 8 | 70,028,573 | 148 | 148 | 138 |
| D8Rat93 | 8 | 70,039,735 | 124 | 124 | 128 |
| AA892388 | 8 | 70,581,319 | S | S | W |
| D8Mgh5 | 8 | 71,363,751 | 128 | 128 | 130 |
| D8Rat101 | 8 | 71,842,326 | 240 | 240 | 246 |
| D8Arb15 | 8 | 71,862,682 | 147 | 147 | 133 |
| D8Rat79 | 8 | 72,444,991 | 123 | 123 | 135 |
| D8Rat206 | 8 | 72,544,435 | 231 | 231 | 233 |
| D8Rat84 | 8 | 72,621,519 | 162 | 162 | 154 |
| D8Mgh17 | 8 | 73,121,059 | 126 | 126 | 126 |
| D8Rat146 | 8 | 73,124,457 | 139 | 139 | 149 |
| D8Rat140 | 8 | 74,223,239 | 167 | 167 | 157 |
| D20Rat49 | 20 | 8,286,760 | 128 | 128 | 130 |
| D20Mgh5 | 20 | 9,302,201 | 120 | 120 | 118 |
| D20Rat31 | 20 | 10,410,231 | 227 | 219 | 227 |
| D20Rat59 | 20 | 11,035,835 | 104 | 104 | 90 |
| D20Rat4 | 20 | 12,141,648 | 167 | 167 | 171 |
| Gstt2 | 20 | 13,221,934 | S | S | W |
| D20Rat60 | 20 | 14,612,602 | 200 | 159 | 159 |
| D20Mit5 | 20 | 18,259,570 | 250 | 250 | 250 |
| D20Rat5 | 20 | 18,425,634 | 130 | 130 | 130 |