Table 3.

Optimization of conditions for arylative cyclization of 1a.

#	[Pd] source	Ligand	Base	Temperature	12a:13a Ratioa	Yield of 12a, %b
1	Pd(OAc)2	dppp	KOAc	120	-	0
2	Pd(OAc)2	dppe	KOAc	120	-	0
3	Pd(OAc)2	Ph2P(CH2)5PPh2	KOAc	120	-	0
4	Pd(OAc)2	dppf	KOAc	100	90:10	10
5	Pd(OAc)2	d-t-Bupf	KOAc	100	90:10	12
6	Pd(OAc)2	d-i-Prpf	KOAc	120	95:5	12
7	Pd(OAc)2	d-i-Prpf	Cs2CO3	120	-	0
8	Pd(OAc)2	d-i-Prpf	Et3N	120	99:1	45
9	Pd(OAc)2	d-i-Prpf	EtN(i-Pr)2	120	100:0	60
10	PdCl2	d-i-Prpf	EtN(i-Pr)2	120	100:0	31
11	Pd(dba)2	d-i-Prpf	EtN(i-Pr)2	120	100:0	20
12	PdCl2(CH3CN)2	d-i-Prpf	EtN(i-Pr)2	120	100:0	30
13	Pd(OAc)2	d-i-Prpf	Bu4NBr	120	100:0	20
14	Pd(OAc)2	d-i-Prpf	DABCO	100	100:0	70c
15	Pd(OAc)2	dppf	DABCO	110	100:0	81
16	Pd(OAc)2	d-t-Bupf	DABCO	110	100:0	80
17	Pd(OAc)2	d-i-Prpf	DABCO	110	100:0	95
18	Pd(OAc)2	d-i-Prpf	DABCO	120	100:0	89d

^aProduct ratios determined by GC/MS analysis.

^bYield determined by GC/MS analysis.

^cYield after 24 hrs.

^dIsolated yield after 6 hrs.