Table 2.
Over-representation of ESR, DDR and CC genes in cdc13-1 dataset and QT clusters
| Gene set (size) | ESR | DDR | CC |
| QT1 (242) | 33% | 57% | 35% |
| QT2 (160) | 28% | 51% | 24% |
| QT3 (77) | 51% | 74% | 49% |
| QT4 (28) | 57% | 71% | 39% |
| QT5 (23) | 22% | 61% | 26% |
| QT6 (21) | 0% | 57% | 81% |
| QT7 (9) | 44% | 78% | 11% |
| QT8 (8) | 38% | 63% | 25% |
| QT9 (5) | 0% | 100% | 100% |
| QT10 (8) | 0% | 25% | 63% |
| QT11 (6) | 50% | 67% | 50% |
| QT12 (8) | 0% | 38% | 100% |
| QT13 (7) | 0% | 71% | 100% |
| Altered in cdc13-1 (647) | 41% (P ≤ 10e-15) | 40% (P ≤ 10e-15) | 31% (P ≤ 10e-15) |
| S. cerevisiae genome | 14% | 25% | 22% |
Table showing percentage of genes in the S. cerevisiae genome, cdc13-1 dataset and QT clusters 1-13 that have been shown to be differentially expressed in response to environmental stress, DNA damage, and cell cycle progression. Hypergeometric tests were used to determine whether each class of gene was over-represented in the QT clusters. Percent values shown in bold are statistically over-represented. Gene proportions in the cdc13-1 dataset were compared to expression across the S. cerevisiae genome, while gene proportions in each QT set were compared to proportions across the cdc13-1 experiment. ESR, all genes involved in the environmental stress response (868) [24]; DDR, all genes that are altered in response to either methyl methanesulfonate, ionizing radiation or a single HO cut (1,529) [27,28]; CC, all genes known to be cell cycle regulated (1,271) [30]