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. Author manuscript; available in PMC: 2009 Oct 13.
Published in final edited form as: Proteomics. 2008 Oct;8(20):4259–4272. doi: 10.1002/pmic.200700480

Figure 6.

Figure 6

Potential roles of the proteins in osteoclastogenesis. This figure depicts how CMCs migrate from blood vessels to bone surface and activate into bone-resorbing osteoclasts. The major process, on which the proteins may exert their effects, was indicated by arrows. Plus sign means stimulate, minus sign means inhibit. ↓↑ Up- or downregulation in low BMD samples; Inline graphicCMCs;Inline graphic monocyte;Inline graphic monocyte committed to osteoclast differentiation; Inline graphic multinucleate cell; Inline graphic mature osteoclast; and Inline graphic active osteoclast.