Table 2.
Summary of the SNPs most significantly associated to the length of RR interval
| MICROS | ORKNEY | ERF | POOLED | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Chr | Position | MA | MAF | beta (se) |
p | MAF | beta (se) |
p | MAF | beta (se) |
p | beta (se) |
p | gene |
| rs885389 | 12 | 130187715 | A | 0.30 | -0.25 (0.05) |
0.0001 | 0.30 | -0.12 (0.06) |
0.0479 | 0.35 | -0.13 (0.06) |
0.0345 | -0.17 (0.03) |
3.88*10-8 | GPR133 |
| rs1725789 | 12 | 130175479 | G | 0.24 | -0.23 (0.05) |
0.0006 | 0.23 | -0.18 (0.06) |
0.0099 | 0.27 | -0.11 (0.06) |
0.0861 | -0.18 (0.03) |
1.48*10-7 | GPR133 |
| rs12554086 | 9 | 81997323 | A | 0.39 | -0.22 (0.05) |
0.0002 | 0.30 | -0.05 (0.06) |
0.3756 | 0.25 | -0.18 (0.06) |
0.0056 | -0.16 (0.03) |
3.59*10-7 | - |
| rs1024020 | 4 | 131357211 | A | 0.21 | 0.12 (0.06) |
0.0956 | 0.20 | 0.21 (0.07) |
0.0048 | 0.22 | 0.24 (0.06) |
0.0003 | 0.18 (0.04) |
4.34*10-7 | - |
| rs3117035 | 6 | 33194227 | A | 0.48 | -0.2 (0.04) |
0.0004 | 0.37 | -0.17 (0.06) |
0.0049 | 0.45 | -0.03 (0.06) |
0.5893 | -0.14 (0.03) |
1.10*10-6 | - |
| rs1541010 | 10 | 13795550 | A | 0.28 | 0.13 (0.05) |
0.0513 | 0.33 | 0.21 (0.06) |
0.0004 | 0.35 | 0.13 (0.06) |
0.0320 | 0.15 (0.03) |
1.11*10-6 | FRMD4A |
| rs10514995 | 5 | 65775195 | G | 0.36 | 0.13 (0.05) |
0.0359 | 0.31 | 0.12 (0.06) |
0.0660 | 0.40 | 0.21 (0.06) |
0.0003 | 0.15 (0.03) |
1.12*10-6 | - |
| rs2717128 | 18 | 73116620 | G | 0.14 | -0.26 (0.06) |
0.0019 | 0.13 | -0.23 (0.08) |
0.0072 | 0.24 | -0.1 (0.06) |
0.1070 | -0.19 (0.04) |
1.17*10-6 | - |
| rs7318731 | 13 | 21607670 | A | 0.48 | -0.09 (0.04) |
0.1147 | 0.46 | -0.19 (0.05) |
0.0007 | 0.42 | -0.16 (0.05) |
0.0045 | -0.14 (0.03) |
1.24*10-6 | - |
| rs3743200 | 15 | 77061101 | A | 0.27 | 0.15 (0.05) |
0.0214 | 0.27 | 0.21 (0.06) |
0.0014 | 0.23 | 0.13 (0.06) |
0.0648 | 0.16 (0.03) |
1.54*10-6 | RASGRF1 |
| rs4352210 | 2 | 37604484 | A | 0.37 | -0.19 (0.05) |
0.0020 | 0.47 | -0.2 (0.06) |
0.0007 | 0.44 | -0.04 (0.05) |
0.5208 | -0.14 (0.03) |
1.55*10-6 | - |
| rs1317632 | 5 | 65782224 | A | 0.33 | 0.13 (0.05) |
0.0429 | 0.28 | 0.13 (0.06) |
0.0401 | 0.38 | 0.19 (0.06) |
0.0010 | 0.15 (0.03) |
1.99*10-6 | - |
| rs1484948 | 11 | 41809240 | G | 0.32 | 0.16 (0.05) |
0.0095 | 0.23 | 0.23 (0.06) |
0.0006 | 0.23 | 0.07 (0.07) |
0.2878 | 0.16 (0.03) |
2.13*10-6 | - |
| rs2670321 | 3 | 100649797 | C | 0.27 | -0.25 (0.05) |
0.0001 | 0.31 | -0.13 (0.06) |
0.0341 | 0.35 | -0.05 (0.06) |
0.3857 | -0.16 (0.03) |
2.21*10-6 | - |
| rs12552736 | 9 | 25439122 | G | 0.06 | 0.28 (0.1) |
0.0223 | 0.09 | 0.13 (0.1) |
0.2013 | 0.12 | 0.32 (0.08) |
0.0003 | 0.25 (0.05) |
2.25*10-6 | - |
| rs4132509 | 1 | 242009707 | A | 0.21 | -0.18 (0.06) |
0.0104 | 0.19 | -0.09 (0.07) |
0.2325 | 0.18 | -0.26 (0.07) |
0.0005 | -0.18 (0.04) |
2.28*10-6 | AKT3 |
| rs1329554 | 9 | 82010698 | A | 0.37 | -0.18 (0.05) |
0.0034 | 0.28 | -0.06 (0.06) |
0.3076 | 0.25 | -0.2 (0.06) |
0.0023 | -0.15 (0.03) |
2.32*10-6 | - |
| rs17706439 | 1 | 211922211 | A | 0.17 | 0.17 (0.06) |
0.0232 | 0.14 | 0.27 (0.08) |
0.0014 | 0.19 | 0.13 (0.07) |
0.0705 | 0.18 (0.04) |
3.07*10-6 | - |
| rs2015015 | 10 | 13806698 | A | 0.33 | 0.1 (0.05) |
0.1115 | 0.37 | 0.17 (0.06) |
0.0044 | 0.38 | 0.18 (0.06) |
0.0036 | 0.14 (0.03) |
3.74*10-6 | FRMD4A |
| rs10496166 | 2 | 68917413 | A | 0.13 | 0.29 (0.07) |
0.0007 | 0.20 | 0.1 (0.07) |
0.1805 | 0.17 | 0.16 (0.07) |
0.0380 | 0.18 (0.04) |
3.99*10-6 | - |
| rs3110127 | 8 | 60292850 | A | 0.33 | -0.18 (0.05) |
0.0037 | 0.31 | -0.03 (0.06) |
0.6934 | 0.33 | -0.21 (0.06) |
0.0005 | -0.15 (0.03) |
4.07*10-6 | - |
| rs1447537 | 2 | 84100097 | A | 0.31 | -0.18 (0.05) |
0.0056 | 0.24 | -0.1 (0.06) |
0.1415 | 0.33 | -0.15 (0.06) |
0.0119 | -0.15 (0.03) |
4.11*10-6 | - |
| rs13300284 | 9 | 25442812 | A | 0.04 | 0.4 (0.12) |
0.0075 | 0.08 | 0.17 (0.1) |
0.1310 | 0.10 | 0.26 (0.09) |
0.0043 | 0.26 (0.06) |
4.34*10-6 | - |
| rs744016 | 22 | 25372106 | A | 0.20 | -0.21 (0.06) |
0.0043 | 0.15 | -0.2 (0.07) |
0.0094 | 0.17 | -0.09 (0.07) |
0.2264 | -0.17 (0.04) |
4.75*10-6 | - |
| rs2125230 | 1 | 241952471 | A | 0.21 | -0.18 (0.06) |
0.0124 | 0.19 | -0.07 (0.07) |
0.3226 | 0.18 | -0.27 (0.07) |
0.0005 | -0.17 (0.04) |
4.93*10-6 | AKT3 |
name: SNP name; chr: chromosome; position: position in basepair (bp); MA: minor allele (for the top 25 SNPs minor alleles were the same in the three populations), MAF: Minor Allele Frequency; beta(se): SNP effect size and standard error; p: p-value for association; gene: gene in which the SNP is located.