Table 3.
Summary of the SNPs most significantly associated to the length of QT interval
| MICROS | ORKNEY | ERF | POOLED | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Chr | Position | MA | MAF | beta (se) |
p | MAF | beta (se) |
p | MAF | beta (se) |
p | beta (se) |
p | gene |
| rs2880058 | 1 | 160281256 | G | 0.32 | 0.25 (0.05) |
6.96*10-6 | 0.35 | 0.12 (0.06) |
0.0443 | 0.44 | 0.19 (0.06) |
0.0023 | 0.19 (0.03) |
2.00*10-10 | - |
| rs6670339 | 1 | 160322430 | G | 0.34 | 0.24 (0.05) |
2.01*10-5 | 0.34 | 0.09 (0.06) |
0.1255 | 0.45 | 0.16 (0.05) |
0.0065 | 0.17 (0.03) |
1.03*10-8 | NOS1AP |
| rs2478333 | 13 | 47060559 | A | 0.33 | 0.22 (0.05) |
0.0001 | 0.37 | 0.19 (0.06) |
0.0013 | 0.33 | 0.08 (0.06) |
0.1995 | 0.17 (0.03) |
4.34*10-8 | - |
| rs10494366 | 1 | 160352309 | C | 0.35 | 0.21 (0.05) |
0.0001 | 0.35 | 0.12 (0.06) |
0.0453 | 0.49 | 0.13 (0.05) |
0.0282 | 0.16 (0.03) |
8.72*10-8 | NOS1AP |
| rs4657140 | 1 | 160327889 | A | 0.35 | 0.21 (0.05) |
0.0001 | 0.35 | 0.12 (0.06) |
0.0496 | 0.49 | 0.13 (0.05) |
0.0282 | 0.16 (0.03) |
9.38*10-8 | NOS1AP |
| rs1415259 | 1 | 160351933 | G | 0.35 | 0.21 (0.05) |
0.0001 | 0.35 | 0.12 (0.06) |
0.0496 | 0.49 | 0.13 (0.05) |
0.0282 | 0.16 (0.03) |
9.38*10-8 | NOS1AP |
| rs4656349 | 1 | 160316448 | G | 0.33 | 0.24 (0.05) |
2.77*10-5 | 0.29 | 0.06 (0.06) |
0.3310 | 0.42 | 0.15 (0.05) |
0.0140 | 0.16 (0.03) |
1.74*10-7 | NOS1AP |
| rs8015016 | 14 | 95192161 | G | 0.20 | -0.2 (0.06) |
0.0023 | 0.21 | -0.21 (0.07) |
0.0045 | 0.19 | -0.13 (0.07) |
0.0765 | -0.18 (0.04) |
5.27*10-7 | TCL6 |
| rs1172416 | 13 | 47119744 | G | 0.30 | 0.15 (0.05) |
0.0130 | 0.30 | 0.19 (0.06) |
0.0023 | 0.25 | 0.16 (0.06) |
0.0262 | 0.16 (0.03) |
5.80*10-7 | - |
| rs6845865 | 4 | 149194052 | G | 0.21 | 0.2 (0.05) |
0.0020 | 0.10 | 0.19 (0.09) |
0.0635 | 0.23 | 0.17 (0.06) |
0.0121 | 0.19 (0.04) |
6.84*10-7 | ARHGAP10 |
| rs789852 | 3 | 195808387 | A | 0.08 | 0.39 (0.08) |
5.37*10-5 | 0.07 | 0.19 (0.11) |
0.0930 | 0.11 | 0.15 (0.08) |
0.0884 | 0.25 (0.05) |
6.91*10-7 | LOC100132805 |
| rs652889 | 3 | 61769094 | A | 0.36 | -0.07 (0.05) |
0.2391 | 0.26 | -0.23 (0.06) |
0.0006 | 0.46 | -0.2 (0.05) |
0.0005 | -0.15 (0.03) |
7.46*10-7 | PTPRG |
| rs4318720 | 4 | 118551703 | A | 0.09 | 0.26 (0.08) |
0.0028 | 0.06 | 0.32 (0.12) |
0.0120 | 0.05 | 0.27 (0.12) |
0.0455 | 0.28 (0.06) |
8.11*10-7 | - |
| rs7728043 | 5 | 5950694 | G | 0.48 | -0.18 (0.04) |
0.0004 | 0.41 | -0.1 (0.06) |
0.1170 | 0.41 | -0.13 (0.05) |
0.0281 | -0.14 (0.03) |
1.03*10-6 | - |
| rs2650951 | 3 | 123851037 | A | 0.05 | -0.45 (0.1) |
5.74*10-5 | 0.03 | 0.06 (0.15) |
0.7143 | 0.10 | -0.27 (0.09) |
0.0052 | -0.29 (0.06) |
1.09*10-6 | - |
| rs1348582 | 12 | 20423023 | G | 0.18 | 0.24 (0.06) |
0.0005 | 0.18 | 0.11 (0.07) |
0.1458 | 0.07 | 0.27 (0.1) |
0.0178 | 0.2 (0.04) |
1.42*10-6 | PDE3A |
| rs12476289 | 2 | 179350220 | A | 0.07 | 0.27 (0.08) |
0.0056 | 0.03 | 0.42 (0.16) |
0.0139 | 0.06 | 0.26 (0.11) |
0.0224 | 0.29 (0.06) |
1.51*10-6 | TTN |
| rs1150461 | 5 | 5964381 | A | 0.40 | -0.17 (0.05) |
0.0010 | 0.36 | -0.12 (0.06) |
0.0448 | 0.36 | -0.12 (0.06) |
0.0575 | -0.14 (0.03) |
1.65*10-6 | - |
| rs10488031 | 7 | 37043379 | A | 0.07 | -0.25 (0.09) |
0.0141 | 0.10 | -0.35 (0.09) |
0.0003 | 0.06 | -0.14 (0.11) |
0.2695 | -0.26 (0.05) |
1.97*10-6 | ELMO1 |
| rs1932933 | 1 | 160384670 | A | 0.33 | 0.2 (0.05) |
0.0004 | 0.38 | 0.14 (0.05) |
0.0209 | 0.48 | 0.08 (0.05) |
0.1794 | 0.14 (0.03) |
1.99*10-6 | NOS1AP |
| rs1533317 | 4 | 35087026 | A | 0.46 | 0.12 (0.05) |
0.0225 | 0.49 | 0.14 (0.05) |
0.0174 | 0.46 | 0.15 (0.05) |
0.0062 | 0.14 (0.03) |
2.00*10-6 | - |
| rs7523798 | 1 | 160413455 | G | 0.42 | 0.17 (0.05) |
0.0016 | 0.35 | 0.15 (0.06) |
0.0157 | 0.32 | 0.1 (0.06) |
0.1206 | 0.14 (0.03) |
2.09*10-6 | NOS1AP |
| rs2562829 | 2 | 179312611 | C | 0.07 | 0.28 (0.08) |
0.0039 | 0.02 | 0.41 (0.17) |
0.0241 | 0.07 | 0.25 (0.1) |
0.0310 | 0.28 (0.06) |
2.27*10-6 | TTN |
| rs11723116 | 4 | 118500818 | A | 0.18 | 0.18 (0.06) |
0.0053 | 0.19 | 0.22 (0.07) |
0.0024 | 0.18 | 0.1 (0.07) |
0.1766 | 0.17 (0.04) |
2.46*10-6 | - |
| rs7601713 | 2 | 157261106 | A | 0.23 | -0.16 (0.05) |
0.0146 | 0.27 | -0.18 (0.06) |
0.0052 | 0.19 | -0.15 (0.07) |
0.0439 | -0.16 (0.03) |
2.49*10-6 | - |
name; chr: chromosome; position: position in basepair (bp); MA: minor allele (for the top 25 SNPs minor alleles were the same in the three populations), MAF: Minor Allele Frequency; beta(se): SNP effect size and standard error; p: p-value for association; gene: gene in which the SNP is located.