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. 2009 Oct 30;5(10):e1000548. doi: 10.1371/journal.pcbi.1000548

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Ashyraliyev et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The distribution of regulatory weights for each regulator (columns) and regulated gene (rows), is shown for OLS fits (above) and WLS fits (below). Number triplets show how many parameter estimates (from independently obtained optimisation solutions) fall into the regulatory categories of ‘repression’ (parameter values ; left), ‘no interaction’ (between and ; middle), and ‘activation’ (parameter values ; right). Background colours indicate whether a majority of the weights for a particular interaction show repression (red), activation (green) or no interaction (blue). Dark background means that all solutions fall into the same category; light colours indicate ambiguity in the prediction where some solutions fall into a different category than others. Note that the regulatory topology predicted by WLS fits with fixed Hkb weights (WLSfh) is exactly the same as that for WLS fits (not shown).

Inline graphic — The distribution of regulatory weights for each regulator (columns) and regulated gene (rows), is shown for OLS fits (above) and WLS fits (below). Number triplets show how many parameter estimates (from independently obtained optimisation solutions) fall into the regulatory categories of ‘repression’ (parameter values ; left), ‘no interaction’ (between and ; middle), and ‘activation’ (parameter values ; right). Background colours indicate whether a majority of the weights for a particular interaction show repression (red), activation (green) or no interaction (blue). Dark background means that all solutions fall into the same category; light colours indicate ambiguity in the prediction where some solutions fall into a different category than others. Note that the regulatory topology predicted by WLS fits with fixed Hkb weights (WLSfh) is exactly the same as that for WLS fits (not shown).