Table 2.
Association Between Body Mass Index and Risk of Pancreatic Cancera
| All Participants |
Men |
Women |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. |
No. |
No. |
||||||||
| Patients | Controls | AOR (95% CI)b | P Value | Patients | Controls | AOR (95%CI) | Patients | Controls | AOR (95%CI) | |
| Age, y | ||||||||||
| Meanc |
841 |
753 |
1.55 (1.32-1.84) |
<.001 |
496 |
472 |
1.80 (1.45-2.23) |
345 |
281 |
1.32 (1.02-1.70) |
| 14-19 |
841 |
751 |
1.50 (1.26-1.77) |
<.001 |
496 |
471 |
1.51 (1.22-1.85) |
345 |
280 |
1.51 (1.13-2.02) |
| 20-29 |
840 |
751 |
1.53 (1.30-1.79) |
<.001 |
496 |
471 |
1.60 (1.31-1.96) |
344 |
280 |
1.46 (1.12-1.89) |
| 30-39 |
836 |
751 |
1.48 (1.28-1.71) |
<.001 |
496 |
472 |
1.65 (1.36-2.01) |
340 |
279 |
1.30 (1.05-1.62) |
| 40-49 |
809 |
732 |
1.25 (1.10-1.42) |
.001 |
479 |
457 |
1.39 (1.16-1.65) |
330 |
275 |
1.14 (0.95-1.38) |
| 50-59 |
680 |
608 |
1.16 (1.02-1.32) |
.02 |
401 |
376 |
1.34 (1.12-1.60) |
279 |
232 |
1.00 (0.83-1.21) |
| 60-69 |
413 |
331 |
1.08 (0.91-1.28) |
.41 |
237 |
211 |
1.30 (1.01-1.66) |
176 |
120 |
0.92 (0.71-1.18) |
| No Diabetes | Ever Smokers | Never Smokers | ||||||||
| Meanc |
620 |
657 |
1.66 (1.37-2.01) |
<.001 |
456 |
354 |
1.75 (1.37-2.22) |
385 |
399 |
1.46 (1.16-1.84) |
| 14-19 |
620 |
656 |
1.54 (1.27-1.85) |
<.001 |
456 |
353 |
1.61 (1.27-2.03) |
385 |
398 |
1.45 (1.14-1.86) |
| 20-29 |
620 |
656 |
1.71 (1.36-2.06) |
<.001 |
456 |
353 |
1.71 (1.36-2.16) |
384 |
398 |
1.44 (1.15-1.80) |
| 30-39 |
616 |
655 |
1.61 (1.37-1.91) |
<.001 |
454 |
353 |
1.70 (1.37-2.12) |
382 |
398 |
1.37 (1.12-1.67) |
| 40-49 |
595 |
637 |
1.28 (1.10-1.48) |
.008 |
446 |
351 |
1.32 (1.10-1.59) |
363 |
381 |
1.22 (1.02-1.46) |
| 50-59 |
488 |
525 |
1.16 (0.99-1.34) |
.04 |
375 |
301 |
1.18 (0.99-1.41) |
305 |
307 |
1.17 (0.96-1.42) |
| 60-69 | 287 | 281 | 1.00 (0.87-1.21) | .97 | 218 | 176 | 1.11 (0.87-1.42) | 195 | 155 | 1.05 (0.83-1.34) |
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval.
a
Body mass index was calculated as weight in kilograms divided by height in meters squared. Data on body mass index at early age was missing from 3 controls and 1 patient.
b
The AOR of pancreatic cancer per 5-unit increase in body mass index was estimated by a logistic regression model that included age, race, sex, smoking status, diabetes status, alcohol consumption, and family history of cancer. Sex and smoking status were omitted from the model in the analyses of sex and smoking strata.
c
Indicates a mean body mass index from the ages of 14 to 59 years.