Table 5.
Body Mass Index at Different Age Periods and Overall Survival of Patients With Pancreatic Cancera
| No. of Patients | No. of Deaths | Survival, Median (IQR), mob | P Valuec | Adjusted HR (95% CI)d | P Value | |
|---|---|---|---|---|---|---|
| Age period, y | ||||||
| 14-19 to 20-29 | ||||||
| Normal weight |
415 |
241 |
14.7 (8.8-27.5) |
|
1 [Reference] |
|
| Overweight |
127 |
77 |
15.1 (7.5-26.4) |
.05 |
1.15 (0.85-1.56) |
.29 |
| Obese |
15 |
8 |
15.2 (9.8-23.8) |
.28 |
0.86 (0.38-1.96) |
.72 |
| 30-39 to 50-59 | ||||||
| Normal weight |
237 |
123 |
16.9 (9.8-30.1) |
|
1 [Reference] |
|
| Overweight |
252 |
155 |
13.9 (8.5-29.0) |
.11 |
1.19 (0.90-1.59) |
.22 |
| Obese |
117 |
73 |
13.5 (7.5-23.8) |
.02 |
1.75 (1.23-2.50) |
.002 |
| 60-69 to 70-79 | ||||||
| Normal weight |
83 |
43 |
16.5 (7.7-30.4) |
|
1 [Reference] |
|
| Overweight |
119 |
65 |
15.3 (8.3-18.6) |
.83 |
0.99 (0.63-1.58) |
.99 |
| Obese |
87 |
63 |
11.4 (7.6-16.8) |
.003 |
1.76 (1.09-2.84) |
.02 |
| All ages for year prior to recruitment | ||||||
| Normal weight |
191 |
101 |
18.2 (9.9-32.6) |
|
1 [Reference] |
|
| Overweight |
255 |
146 |
13.7 (8.1-28.0) |
.04 |
1.26 (0.94-1.69) |
.04 |
| Obese |
163 |
105 |
13.5 (8.4-19.7) |
<.001 |
1.86 (1.35-2.56) |
<.001 |
| Resected tumorse | ||||||
| Normal weight |
46 |
15 |
35.0 (30.2-39.9) |
|
1 [Reference] |
|
| Overweight |
59 |
19 |
32.3 (27.7-36.9) |
.52 |
1.44 (0.70-2.96) |
.32 |
| Obese |
33 |
17 |
24.6 (18.8-30.4) |
.006 |
3.35 (1.50-7.49) |
.003 |
| Unresected tumors | ||||||
| Normal weight |
145 |
86 |
14.0 (7.8-23.3) |
|
1 [Reference] |
|
| Overweight |
196 |
127 |
14.5 (6.3-17.8) |
.04 |
1.22 (0.88-1.69) |
.24 |
| Obese |
130 |
88 |
12.1 (7.2-16.7) |
.007 |
1.64 (1.15-2.33) |
.006 |
| Metastatic disease | ||||||
| Normal weight |
82 |
47 |
12.1 (7.0-22.9) |
|
1 [Reference] |
|
| Overweight |
133 |
85 |
11.5 (5.8-17.7) |
.16 |
1.05 (0.72-1.51) |
.81 |
| Obese | 71 | 50 | 8.8 (5.4-13.2) | .001 | 1.57 (1.03-2.40) | .04 |
Abbreviations: CI, confidence interval; HR, hazard ratio; IQR, interquartile range.
a
Body mass index was calculated as weight in kilograms divided by height in meters squared.
b
The IQR is the 25th and 75th percentile.
c
Calculated using the log-rank test.
d
Model included tumor stage, tumor resection, diabetes status, and serum carbohydrate antigen 19-9 level at diagnosis (when appropriate).
e
Median survival time could not be calculated so mean and 95% CI is presented.