Table 2.
Brain region activation associated with IL-1β and sTNFrII pro-inflammatory markers during grief elicitation (Deceased > Stranger contrast) (N = 18). All regions reported at the threshold of .001, uncorrected, 10 voxels.
| Region | MNI Coordinates (x,y,z) | Z | T | p-value (voxels) | ||
|---|---|---|---|---|---|---|
| IL-1β | ||||||
| Cuneus (BA 19) | 22 | -68 | 32 | 4.16 | 5.72 | <0.001 (55) |
| Inferior frontal (BA 46) | -46 | 36 | 8 | 3.95 | 5.26 | <0.001 (31) |
| Inferior frontal (BA 44) | 48 | 16 | 16 | 3.71 | 4.78 | <0.001 (12) |
| Inferior frontal (BA 44) | -56 | 24 | 26 | 3.62 | 4.60 | <0.001 (20) |
| Inferior frontal (BA 46) | 32 | 26 | 14 | 3.44 | 4.28 | <0.001 (11) |
| Inferior frontal (BA 44) | 42 | 16 | 30 | 3.44 | 4.27 | <0.001 (11) |
| Inferior frontal (BA 44) | 34 | 16 | 28 | 3.34 | 4.10 | <0.001 (10) |
| sTNFrII | ||||||
| Fusiform gyrus (BA 37) | -36 | -58 | -12 | 4.04 | 5.45 | <0.001 (184) |
| Putamen | -24 | -26 | -4 | 3.83 | 5.01 | <0.001 (53) |
| Putamen | 18 | -26 | 0 | 3.64 | 4.64 | <0.001 (42) |
| Cuneus (BA 19) | -28 | -86 | 18 | 3.62 | 4.59 | <0.001 (37) |
| Temporal pole (BA 38) | 28 | 14 | -24 | 3.52 | 4.42 | <0.001 (27) |
| Fusiform gyrus (BA 37) | 40 | -54 | -12 | 3.34 | 4.10 | <0.001 (18) |
| Parahippocampus (BA 36) | -30 | -36 | -24 | 3.18 | 3.83 | <0.001 (11) |