Table 3.
The important set of genes based on topological structure of interaction network. Selecting the nodes that satisfy condition 2 (the articulation nodes among the hub nodes of the network) and condition 3 (the hub nodes of the minimum spanning tree). The inverse of fold changes for down regulated genes is shown. Thus the table includes the genes that are not considered in the experiment or neither up-or downregulated.
| Gene | Regulation | Fold change |
|---|---|---|
| CPNE1 | Up | 2.63 |
| CTSB | Up | 2.78 |
| CTSD | Up | 2.00 |
| MAD1L1 | Up | 3.45 |
| MEF2C | Up | 2.21 |
| PCM1 | Up | 2.01 |
| PRKAR2B | Up | 2.80 |
| PSMD7 | Up | 2.01 |
| PTPN1 | Up | 2.06 |
| RBL2 | Up | 2.62 |
| RGS20 | Up | 2.20 |
| SOD2 | Up | 2.10 |
| ADSL | Down | 2.23 |
| ATM | Down | 2.09 |
| BID | Down | 2.09 |
| CASP1 | Down | 3.07 |
| CBLB | Down | 2.32 |
| CCNB2 | Down | 2.32 |
| CDC7 | Down | 2.17 |
| CHEK1 | Down | 2.06 |
| CTTN | Down | 2.63 |
| DDX17 | Down | 2.13 |
| DGCR14 | Down | 2.04 |
| ETS1 | Down | 2.50 |
| FOS | Down | 2.94 |
| GLUL | Down | 5.13 |
| GNAQ | Down | 2.39 |
| ID2 | Down | 2.86 |
| MACF1 | Down | 2.05 |
| MRE11A | Down | 2.61 |
| MYLK | Down | 4.25 |
| NEDD4 | Down | 2.01 |
| PAFAH1B2 | Down | 2.57 |
| PPFIA1 | Down | 2.41 |
| PRKAB2 | Down | 2.56 |
| PRSS23 | Down | 2.47 |
| RAB27A | Down | 2.74 |
| RAB8B | Down | 2.27 |
| RPL31 | Down | 2.08 |
| RRM2 | Down | 2.32 |
| SMARCB1 | Down | 2.14 |
| SNCA | Down | 5.24 |
| TGFB2 | Down | 2.06 |
| THBS1 | Down | 3.70 |
| TNFRSF1A | Down | 2.13 |
| TPM1 | Down | 4.62 |
| XRCC6 | Down | 2.08 |
| DDX19B | Down | 2.09 |
| *GRINL1B | — | — |
| *HIST2H3PS2 | — | — |
| *NA | — | — |
| *RET | — | — |
| *RPL35A | — | — |
| **SMC2 | — | — |
| **SMC4 | — | — |
| **TPI1 | — | — |
| **TUBA4A | — | — |
*These genes are neither up-or downregulated, nor considered in the experiment.
**These genes are from interaction network that satisfy conditions 2 and 3.