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Molecular characterization of mutation hERG 1b 23C>T encoding A8V in patient DNA. A, Schematic of hERG 1b N-terminal sequence encompassing A8V mutation. B, Denaturing high performance liquid chromatography (DHPLC) chromatogram revealing a wild-type (blue peak) and an abnormal elution profile (red peak). C, Corresponding DNA sequencing chromatograms revealing the heterozygote 23C>T missense mutation encoding A8V identified in HERG exon 1b.
