Table I.
Effect of Alanine Mutations on 3′ Phosphatase Activity
Pnkp Mutant | 3′ phosphatase (% of WT) |
5′ kinase (% of WT) |
---|---|---|
D187A | <1 | 110 |
K198A | 82 | 80 |
S211A | <1 | 83 |
G212A | 37 | 90 |
E219A | 51 | 64 |
T222A | 94 | 87 |
R229A | 94 | 87 |
E233A | 45 | 66 |
T251A | 120 | 95 |
K253A | 95 | 83 |
K258A | <1 | 59 |
D277A | <1 | 53 |