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The dsRNA binding sites of TLR3. (A) Residues involved in the interaction on the C-terminal site. (B) Illustrates the NF-κB activity of human TLR3 mutants stimulated with pI:pC. (C) Residues involved in binding at the N-terminal site. Note that each interaction involves two strands of the RNA. The dsRNA molecule may undergo a screw rotation of plus or minus one base pair in the crystal.
