Skip to main content
. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Obstet Gynecol. 2009 Aug;114(2 Pt 1):354–364. doi: 10.1097/AOG.0b013e3181ae98c2

Table 1.

Randomized controlled trials included in systematic review.

Study Inclusion Exclusion Patient characteristics (N women/N fetuses) Follow up (months)
BEAM
Rouse (16)
1997–2004
USA

  • - 24–31 wks

  • - singleton or twins

  • - high risk for spontaneous delivery (PPROM, PTL (4–8 cm), or indicated)

  • - delivery anticipated < 2h

  • - dilatation > 8 cm

  • - PROM < 22 wks

  • - major fetal anomalies

  • - IUFD

  • - HTN/Preeclampsia

  • - MgSO4 C/I or received it in prior 12 h

  • - 2241/2444

  • - 9% twins

  • - 10% PTL

  • - 87% PPROM

 24
ACTOMgSO4
Crowther (13)
1996–2000
Australia-New Zealand

  • - <30 wks

  • - singleton or higher order pregnancy

  • - delivery expected in 24 hrs.

  • - 2nd stage of labor

  • - received MgSO4 this pregnancy

  • - MgSO4 C/I

  • - 1062/1255

  • - 17% multiple

  • - 63% PTL

  • - 9% PPROM

  • - 15% preeclampsia

 24
PREMAG
Marret (15,17)
1997–2003
France

  • - <33 wks

  • - singleton, twin or triplet

  • - delivery expected in 24 hrs.

  • - severe congenital or chromosomal abnormalities

  • - indication for emergency CD

  • - pregnancy-associated vascular disease

  • - CCB, digitalins, or indocin in prior 24 h

  • - betamimetics, aminoglycosides, or steroids in prior 1 h.

  • - MgSO4 C/I

  • - 564/688

  • - 22% multiple

  • - 85% PTL

  • - 61% PPROM

 24
Magpie (14)
1998–2001
International (19 countries)

  • - undelivered

  • - singleton or higher order pregnancy

  • - preeclampsia

  • - clinical uncertainty whether MgSO4 would be beneficial

  • - hypersensitivity to magnesium

  • - hepatic coma

  • - myasthenia gravis

  • - 1544/1593 randomized < 37 weeks gestation

  • - 2–3% multiple*

 18
MagNET (12)
Mittendorf
1995–1997
USA

  • - 24–33 wks

  • - singleton or twins

  • - PTL

  • - NRFHT

  • - clinical evidence of infection or preeclampsia

  • - (did not exclude congenital anomalies)

 Preventive arm:

  • - 57/59

  • - 3.5% twins

  • - 100% PTL

Tocolytic arm:

  • - 92/106

  • - 15% twins

  • - 100% PTL

 18
*

Estimate – uncertain from published data

wks=weeks, PPROM=preterm premature rupture of membrane, PTL=preterm labor, IUFD=intrauterine fetal demise, HTN=hypertension, MgSO4=magnesium sulfate, C/I=contraindication, CD=cesarean delivery, CCB=calcium channel blockers, NRFHT=non reassuring fetal heart tracing, h=hour