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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Obstet Gynecol. 2009 Aug;114(2 Pt 1):354–364. doi: 10.1097/AOG.0b013e3181ae98c2

Table 2.

Methodological review of randomized controlled trials in systematic review.

Study Blinding Randomization Stratification Intent to treat analysis Infant examiner masked to fetal exposure Miscellaneous
BEAM (16)

  • - double

  • - computer

  • - central

  • - urn method

  • - center

  • - GA < 28 vs. ≥ 28 in twin gestations

 Yes Yes

  • - cranial USG read centrally

  • - primary outcome reported for 95.6% of fetuses
ACTOMgS O4 (13)

  • - double

  • - computer

  • - central

  • - blocks of 4,6,&8

  • - center

  • - order of pregnancy

 Yes Yes

  • - outcomes available for 99% of fetuses

  • - masked treatment packs
PREMAG (15,17)

  • - single

  • - computer

  • - central

  • - blocks of 2–16

  • - center

  • - order of pregnancy

  • - GA: < 27, 27–29, 30–32

 Yes Yes

  • - trial stopped before reaching projected sample size due to poor recruitment
Magpie (14)

  • - double

  • - computer

  • - central

  • - minimization method or blocks of 8

  • - country

  • - severity of preeclampsia

  • - order of pregnancy

  • - GA

  • - prior anticonvulsant drugs

 Yes Yes

  • - not all surviving children followed up (outcomes of 73% of a group of predetermined centers)

  • - masked treatment packs
MagNET (12)

  • - tocolytic arm not blinded

  • - preventive arm double blinded

  • - computer

  • - blocks of 6

  • - race

  • - order of pregnancy

  • - GA ≤ 28 vs. > 28 wks

 Yes Yes

  • - no criteria for CP diagnosis

  • - in T arm, crossover allowed

  • - study suspended

GA=gestational age, USG=ultrasound, CP=cerebral palsy, T arm=tocolytic arm of MagNET trial.