Table 3.

Primary and secondary neonatal outcomes of individual trials and definitions of selected outcomes.

	Primary and secondary neonatal outcome	Definitions of selected outcomes
BEAM	Primary: combined outcome of stillbirth or infant death by 1 year of age or moderate or severe CP at 2 yrs Secondary: neonatal complications, mild, moderate, and severe CP, stillbirth and infant death, Bayley Scales of Infant Development-II	CP: presence of at least two out of the following three criteria: minimum 30% delay in gross motor developmental milestones; abnormalities in muscle tone, movement, or deep tendon reflexes; or persistence of primitive, or absence of protective reflexes
ACTOMgSO4	Primary: total pediatric mortality up to age 2, CP, and a combined outcome of death or CP at 2 yrs Secondary: IVH (grade III or IV), cystic PVL, neurosensory disability	CP: tone abnormalities and loss of motor function
PREMAG	Primary: fetal or neonatal mortality before hospital discharge, severe WMI, combined outcome of death or severe WMI Secondary: severe or moderate WMI, non-parenchymal hemorrhage, periventricular cavitary lesions and their extensions, neonatal complications, motor and cognitive development at 2 yrs	Severe WMI: cystic PVL, periventricular parenchymal hemorrhage, or large single unilateral porencephalic cyst (caused by ischemic–hemorrhagic infarction)
Magpie	Primary: combined outcome of death or neurosensory disability (blind, deaf, severe CP, or developmental quotient < -2 standard deviations) at 18 months Secondary: death, neurosensory disability, delayed speech, other disability	Severe CP: not walking or unlikely to walk unaided at 24 months
MagNET	Primary: composite of “adverse pediatric health outcomes” (neonatal IVH, PVL, CP or death) by 18 months of age

CP=cerebral palsy, IVH=intraventricular hemorrhage, PVL=periventricular leukomalacia, WMI=white matter injury