Table 1.

Event-free survival in cooperative group studies in DS AML.

Study protocol (years)	n (DS)	EFS (DS)	EFS (non-DS)	Comments	Ref.
AML-BFM 98 (1998-2003)	66	89% ±4% (3-yr)	53% ±2% (p=0.0001)		[9]
CCG 2891 (1989-1999)	161	77% (6-yr)	33% (p<0.0001)		[7]
Japan (1987-1997)	33	80% ±7%	DS protocol	All <4yo	[34]
Japan (2000-2004)	72	83.3% ±9.1% (4-yr)	DS pr otocol	70/72 <4yo	[35]
MRC AML 10 (1987-1995)	23	70% ±9.6% (5-yr)	59% ±4.6% (p=0.6)	OS, not EFS	[89]
NOPHO 88 (1988-1992)	15	47% (not given)			[32]
NOPHO 93 (1993-2002)	37	81% ±6% (5-yr)			[90]
POG 8498 (1984-1989)	12	100% (4-yr)	33% (p=0.0001)		[27]
POG 8821 (1988-1993)	27	77% ±2.1% (3-yr)	34% ±2.5%		[91]
POG 9421 (1995-1999)	57	76.9% (5-yr)	51.9% (p<0.001)		[74]
Toronto (1990-2003)	18	67% ±11% (5-yr)	DS protocol		[36]