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Kisspeptin exerts a potent activational effect on GnRH neurons in adult female proestrous mice. Perforated-patch, voltage recordings from proestrous female GnRH-GFP neurons (resting membrane potential = −68 mV) in the acute brain slice demonstrate a remarkably intense and prolonged activation by 10 nm kisspeptin (KP-10). [Modified with permission from Han et al., 2005 (70)].
