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. 2009 Sep 21;30(6):713–743. doi: 10.1210/er.2009-0005

Figure 8.

Figure 8

Structural interactions between Kiss1 and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey. A confocal projection (×10; 1-μm optical sections) illustrating the distribution of kisspeptin neurons (green fluorescence, Alexa Fluor 488) in relation to the GnRH neuronal network (red fluorescence, Cy3) in a coronal section of the MBH of an agonadal male rhesus monkey aged 4 yr 3 months. Whereas kisspeptin perikarya were confined to the ARC, those of GnRH extended along the ventral hypothalamic tract (VHT), lateral to the ARC. GnRH innervation of the external zone of the ME was intense. Beaded kisspeptin axons projected to the ME, and at this anteroposterior level GnRH and kisspeptin fibers running in a near horizontal plane were found in close association. 3V, Third ventricle. Scale bar, 100 μm. [Modified with permission from Ramaswamy et al., 2008 (99) © The Endocrine Society].