Table 16.

Dicer mutations with female reproductive phenotypes

Mouse model	Phenotype	Ref.
Dicer1 Zp3-Cre (Dicer cKO in oocytes)	Sterile; defects in spindle organization and chromosome cohesion block completion of meiosis I; increased expression of genes involved in microtubule dynamics, maternal transcripts normally degraded during meiotic maturation, transposons, and putative targets of pseudogene-derived siRNAs	626,627,628,629
Dicer1 Amhr2-Cre (Dicer cKO in ovary, oviduct, uterus)	Sterile; bilateral oviductal cysts sequester embryos and prevent transit to the uterus; decreased ovulation; uteri decidualize normally but are shorter with fewer endometrial glands and demonstrate implantation defects after embryo transfer experiments	631,632,633,634
Dicer1 hypomorphic mutation	Sterile; luteal insufficiency due to diminished vascularity in CLs	636