Table 8.
Mouse models with defects in antral follicle development
| Gene | Reproductive phenotype | Fertility status | Ref. |
|---|---|---|---|
| A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 1 (Adamts1) | Defects in preovulatory follicle development | Subfertile | 341 |
| Inner mitochondrial membrane peptidase 2-like (Immp2l) (transgenic insertion) | Folliculogenesis and ovulation defects | Infertile | 798 |
| Insulin receptor substrate 2 (Irs2) | Small, anovulatory ovaries with reduced numbers of follicles | Infertile | 799 |
| Estrogen receptor α (Esr1; ERα) | Enlarged, cystic and hemorrhagic follicles, and no CLs or evidence of ovulation | Infertile | 300 |
| Estrogen receptor β (Esr2; ERβ) | Block in late antral folliculogenesis and decreased ovulation | Subfertile | 301 |
| Superoxide dismutase 1 (Sod1) | Folliculogenesis defect; failure to maintain pregnancy | Subfertile | 800,801 |
| SRY-box containing gene 3 (Sox3) | Follicular atresia and oogenesis defects | Subfertile | 802 |
| TNF type I receptor superfamily, member 1a (Tnfrsf1a) | Enhanced prepubertal response to gonadotropins; early ovarian senescence | Subfertile | 803 |