Table 9A.
(Continued)
| Gene | Reproductive phenotype | Fertility status | Ref. |
|---|---|---|---|
| Cyclin-dependent kinase inhibitor 1B (Cdkn1b; p27Kip1) | Corpus luteum differentiation failure and granulosa cell hyperplasia | Infertile | 391,392,393 |
| Early growth response 1 (Egr1; NGFI-A); (targeted lacZ insertion) | Down-regulation of LH receptor, not remedied with gonadotropin treatment | Infertile | 813 |
| Early growth response 1 (Egr1; NGFI-A); (targeted neo insertion) | LH insufficiency, loss of estrous cyclicity, no CLs; rescued by treatment with gonadotropins | Infertile | 814 |
| Aminopeptidase puromycin-sensitive (Npepps; Psa) | Lack of CL formation and PRL production causes early pregnancy loss | Infertile | 815 |
| Prostaglandin F receptor (Ptgfr) | Do not undergo parturition, failed luteolysis | Infertile | 816 |
| Prolactin (Prl) | Irregular estrous cycles and impaired pseudopregnancy response | Infertile | 403 |
| Prolactin receptor (Prlr) | Compromised ovulation, fertilization, and preimplantation development in of Prlr null embryos | Infertile | 401,402 |
| MAD homolog 4 (Smad4) (cKO) | Premature luteinization; decreased ovulation with trapped oocytes | Subfertile | 408 |
Although many genes are critical for multiple events during this period, mouse models are categorized based on the principal findings.