Table 1.
Single nucleotide polymorphisms (SNPs) selected for this study
| Minor allele frequencyb | ||||||
|---|---|---|---|---|---|---|
| Gene | SNP IDa | Location | Alternation | Other allele designations | African | Caucasian |
| CYP1A1 | rs4986884 | 3′UTR | T5639C | 3/m3[7,9] | 6.2% | 0.0% |
| CYP1A1 | rs4646903 | 3′UTR | T6235C | 2A/m1[7,9] | 19.0% | 28.3% |
| CYP1B1 | rs1056836 | Exon 3 | val432leu | 3/m1[13,14] | 35.2% | 57.4% |
| CYP3A4 | rs2740574 | Promoter | A-392G | 1B[10,11] | 50.0% | 3.3% |
| CYP17A1 | rs743572 | Promoter | T-34C | A2[8,12] | 33.0% | 40.0% |
| HSD17B1 | rs605059 | Exon 6 | Ser312Gly | -- | 33.3% | 57.1% |
| ER beta | rs1256059 | Intron 7 | C/T | -- | 7.5% | 39.7% |
a
rs 4986884 and rs4646903 have been designated as rs17861087 and rs17861083, respectively, in the Applied Biosystem database.
b
Based on the dataset which includes the largest number of African Americans or Africans (if no data are available for African Americans) along with Caucasians in the NCBI SNP database [18]