Table 3.
Multivariable odds ratios (OR)a and 95% confidence intervals (CI) associated with the selected SNPs by menopausal status
| Pre-menopausal (N=153) | Post-menopausal (N=230) | ||||||
|---|---|---|---|---|---|---|---|
| Genes | Genotypesb | No. of cases | No. of controls | Odds Ratio(95%CI) | No. of cases | No. of controls | Odds Ratio(95%CI) |
| CYP1A1(5639) | TT | 65 | 64 | 1.00 | 92 | 106 | 1.00 |
| TC | 11 | 9 | - | 21 | 8 | - | |
| CC | 2 | 0 | - | 0 | 0 | - | |
| TC+ CC | 13 | 9 | 1.53(0.60 – 3.91) | 21 | 8 | 3.50(1.41 – 8.74) | |
| CYP1A1(6235) | TT | 49 | 39 | 1.00 | 68 | 70 | 1.00 |
| TC | 25 | 26 | 0.68(0.33 – 1.39) | 43 | 41 | 1.09(0.62 – 1.93) | |
| CC | 5 | 9 | 0.40(0.12 – 1.35) | 4 | 4 | 0.99(0.23 – 4.35) | |
| Dominant | 30 | 35 | 0.61(0.31 – 1.18) | 47 | 45 | 1.08(0.62 – 1.89) | |
| Recessive | 5 | 9 | 0.46(0.14 – 1.51) | 4 | 4 | 0.96(0.22 – 4.12) | |
| Dose-effect | P=0.097 | P=0.822 | |||||
| CYP1B | ValVal | 44 | 44 | 1.00 | 62 | 59 | 1.00 |
| ValLeu | 25 | 23 | 1.22(0.59 – 2.52) | 43 | 43 | 0.88(0.49 – 1.59) | |
| LeuLeu | 4 | 7 | 0.55(0.15 – 2.06) | 4 | 13 | 0.20(0.06 – 0.68) | |
| Dominant | 29 | 30 | 1.05(0.53 – 2.06) | 47 | 56 | 0.70(0.40 – 1.23) | |
| Recessive | 4 | 7 | 0.52(0.14 – 1.88) | 4 | 13 | 0.22(0.07 – 0.70) | |
| Dose-effect | P=0.745 | P=0.034 | |||||
| CYP3A4 | GG | 31 | 35 | 1.00 | 51 | 47 | 1.00 |
| AG | 33 | 30 | 1.13(0.56 – 2.29) | 48 | 54 | 0.69(0.39 – 1.25) | |
| AA | 15 | 9 | 1.62(0.61 – 4.34) | 16 | 14 | 0.93(0.39 – 2.20) | |
| Dominant | 48 | 39 | 1.24(0.64 – 2.40) | 64 | 68 | 0.74(0.43 – 1.29) | |
| Recessive | 15 | 9 | 1.52(0.61 – 3.80) | 16 | 14 | 1.12(0.50 – 2.51) | |
| Dose-effect | P=0.362 | P=0.534 | |||||
| CYP17A1 | TT | 36 | 31 | 1.00 | 34 | 51 | 1.00 |
| TC | 27 | 30 | 0.84(0.41 – 1.73) | 55 | 48 | 1.40(0.76 – 2.59) | |
| CC | 12 | 13 | 0.75(0.29 – 1.92) | 20 | 16 | 1.48(0.65 – 3.39) | |
| Dominant | 39 | 43 | 0.81(0.42 – 1.56) | 75 | 64 | 1.42(0.80 – 2.54) | |
| Recessive | 12 | 13 | 0.81(0.33 – 1.96) | 20 | 16 | 1.22(0.58 – 2.59) | |
| Dose-effect | P=0.506 | P=0.269 | |||||
| HSD17B1 | SerSer | 11 | 24 | 1.00 | 29 | 33 | 1.00 |
| SerGly | 39 | 38 | 2.67(1.11 – 6.43) | 56 | 48 | 1.42(0.73 – 2.77) | |
| GlyGly | 18 | 12 | 4.11(1.41 – 12.03) | 24 | 34 | 0.76(0.35 – 1.63) | |
| Dominant | 57 | 50 | 3.00(1.29 – 6.99) | 80 | 82 | 1.14(0.61 – 2.11) | |
| Recessive | 18 | 12 | 2.04(0.87 – 4.76) | 24 | 34 | 0.61(0.32 – 1.15) | |
| Dose-effect | P=0.009 | P=0.507 | |||||
| ERbeta | CC | 55 | 56 | 1.00 | 90 | 83 | 1.00 |
| TC | 22 | 17 | 1.25(0.58 –2.68) | 22 | 29 | 0.64(0.33 – 1.24) | |
| TT | 1 | 1 | 0.89(0.05 – 15.01) | 3 | 3 | 0.60(0.11 – 3.16) | |
| Dominant | 23 | 18 | 1.23(0.58 – 2.60) | 25 | 32 | 0.64(0.34 – 1.19) | |
| Recessive | 1 | 1 | 0.84(0.05 – 14.04) | 3 | 3 | 0.67(0.13 – 3.50) | |
| Dose-effect | P=0.644 | P=0.173 | |||||
a
Adjusted for pack-years of cigarette smoking and education and use of decaffeinated coffee
b
Dominant: comparison between one or two minor alleles and no alleles, Recessive: comparison between two minor alleles and others