Table 4.
Odds ratios (OR)a and 95% confidence intervals (CI) associated with CYP1A1 5639 C-allele in combination of other SNPs
| Other SNPs |
Genotype | CYP1A1 | No. of cases |
No. of controls |
Odds Ratio (95%CI) |
Genotype | No. of cases |
No. of controls |
Odds Ratio (95%CI) |
P-values for interaction |
|---|---|---|---|---|---|---|---|---|---|---|
| CYP3A4 | GG+AG | TT | 131 | 152 | 1.00 | AA | 25 | 18 | 1.00 | |
| TC+CC | 29 | 12 | 3.20 (1.53 – 6.70) | 5 | 5 | 0.71 (0.16 – 3.11) | 0.043 | |||
| CYP17A1 | TT | TT | 60 | 75 | 1.00 | TC+CC | 91 | 95 | 1.00 | |
| TC+CC | 10 | 6 | 2.83 (0.84 – 9.56) | 23 | 11 | 2.31 (1.05 – 5.10) | 0.904 | |||
| HSD17B1 | SerSer | TT | 31 | 54 | 1.00 | SerGly + | 113 | 116 | 1.00 | |
| TC+CC | 9 | 1 | 15.90 (1.82 – 139) | GlyGly | 23 | 16 | 1.73 (0.85 –3.54) | 0.056 | ||
| ERbeta | CC | TT | 115 | 124 | 1.00 | TC+TT | 41 | 46 | 1.00 | |
| TC+CC | 28 | 13 | 2.48 (1.20 – 5.11) | 6 | 4 | 2.13 (0.47 – 9.72) | 0.727 |
a
Adjusted for pack-years of cigarette smoking and education and use of decaffeinated coffee