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Phase 2 data for nilotinib second-line to imatinib failure
| Disease | N | % Response |
|||
|---|---|---|---|---|---|
| Cytogenetic response |
|||||
| CHR | Major | Complete | Overall survival | ||
| CML chronic | 321 | 77 | 57 | 41 | 91% (18 months) |
| CML accelerated | 136 | 26 | 31 | 19 | 81% (12 months) |
| CML blastic | 136 | 11 | 40 | 29 | 42% (12 months) |
Abbreviations: CHR, complete hematologic response; CML, chronic myeloid leukemia; ALL, acute lymphoid leukemia; Ph, Philadelphia chromosome.
