Table 1.

Isolated left ventricular anterior papillary muscle parameters in WT and FKBP12.6 KO mice

	FKBP12.6+/+		FKBP12.6−/−
	Control	ISO	Control	ISO
Force (mN/mm2)	1.2 ± 0.2	2.1 ± 0.2*	0.8 ± 0.1	1.5 ± 0.2*
% Change	45		43
dF/dTmax	32 ± 6	63 ± 7*	24 ± 2	47 ± 5*
% Change	47		47
Tau (ms)	36 ± 3	27 ± 2*	32 ± 2	24 ± 2*
% Change	22		23

Force was normalized to cross-sectional area (mN/mm²). Baseline was determined by averaging a total of 100 ms, 75 ms before, and 25 ms after the stimulus artefact. Peak amplitude (mN/mm²) was baseline to maximal force development. dF/dT_max was the maximal rate of force development (mN/mm²/s) during contraction. The time constant of decay, tau, was determined as the time to reach 37% of initial (maximal) value. Three to five consecutive contractions were averaged to obtain values of a representative contraction. Isoproterenol was added to a final concentration of 1 mM and values calculated at peak response. A total of eight experiments were performed for each group. Values are mean ± SE.

*P ≤ 0.02 within a group. There was no statistical significance between groups.