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Induction of p53-dependent apoptosis by cisplatin. Three murine testicular teratocarcinoma cell lines, the p53-normal F9 (○) and Nulli-SCC1 (◊) lines and the p53-mutant EB16 line (▪), were treated continuously with 10 μM cisplatin. At the time points indicated, the cells were collected and stained with DAPI to quantitate cells with condensed chromatin.
