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PLM regulates NKA the same way PLB modulates SERCA. Unphosphorylated PLB inhibits SERCA by reducing its Ca affinity and unphosphorylated PLM reduces the NKA apparent affinity for internal Na. Phosphorylation of PLB and PLM restores the ion affinity of the pumps and thus enhances the activity of SERCA and NKA, respectively.
