Figure 5.

Comparison of the CSD of VV12532 to the major CSP of E. coli, Thermotoga maritima and Bacillus caldolyticus. (Top) Alignment between the CSD of VV12532 and the major CSP of the indicated species. Protein lengths are indicated on the right. Asterisks and colons mark identical and similar amino acids, respectively. The 11 residues that form the two RNA-binding motifs, RNP-1 and RNP-2, and that are important for CSP function are boxed. Bottom, the known structures of the major CSP of E. coli, T. maritima and B. caldolyticus are shown. The two RNA-binding motifs, RNP-1 and RNP-2 (yellow regions), are on the surface of the CSP. A proposed structure for the CSD of VV12532 is also shown.