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. 2009 Jul 20;37(17):5589–5601. doi: 10.1093/nar/gkp598

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — (A) Schematic representation of the antiparallel folding of the thrombin-binding aptamer (TBA); blue represents guanines that are anti and red guanines that are syn. Positions of 5, 10, 14 and 15 were modified in this study. (B) Molecular representation: the upper left quadrant shows a lateral view of the TBA and the lower right quadrant a view from the top of the molecule [dG5(syn) and dG14(anti) in the lower quartet as well as dG10(syn) and dG15(syn) in the upper quartet are indicated].