Figure 5.

Developmental potential of the gametes with YY1 KD. The germ cells with YY1 KD were also tested through breeding the male F1 mice (pScio-YY1, Pro-Cre) (A) and the female F1 mice (pSico-YY1, Zp3-Cre) (B) with their littermates. These two breeding experiments were summarized as shown on the left. The two graphs on the right represent the birth weight profiles derived from the 1-day-old neonates of these two breeding experiments. The neonates were analyzed in terms of their birth weights. Each mouse was first categorized according to its genotype [carrier (red) versus noncarrier (blue)]. The relative weight percentile for each mouse was calculated through dividing its weight by the averaged value for its litter. This relative weight value was used to further classify each mouse into different categories ranging from 65% to 125% as shown on the x-axis. The total number of mice in each weight category is plotted as a value on the y-axis.