Table 1.

Number of topo II sites identified in eight well-characterized human replication origins. Their similarities to the mammalian topo II consensus sequence, as well as the references where the origins were initially described are also indicated

Replication origin	Number of sites	Similarity	Reference
Human c-myc	1	12/12	(46)
Human Ors8	4	10/12 (three copies), 11/12	(19)
Human lamin B2	2	11/12	(47)
Human β-globin	2	10/12, 12/12	(48)
Human hsp70	1	11/12	(49)
Human Top1	2	10/12	(50)
Human DNMT1 (C3)	1	11/12	(51)
Human rDNA	5	11/12 (four copies), 12/12	(52)