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. 2009 Sep 24;106(40):17101–17104. doi: 10.1073/pnas.0907147106

Fig. 1.

Fig. 1.

Survival and cancer phenotypes of Pol ε proofreading-deficient mice. (A) Kaplan-Meier survival estimates. Mice were followed for long-term survival and observed daily until moribund or unexpected natural death. Dark red indicates Polee/e (n = 36) and Pole+/e (n = 35) in C57BL/6 genetic background after removal of the neomycin selection cassette (Neo−); light red indicates Polee/e (n = 35) and Pole+/e (n = 45) in a mixed C57BL/6:129/Sv genetic background with the neomycin selection cassette still present (Neo+); blue indicates Pold1e/e (n = 40) in C57BL/6 (Neo−); purple indicates Polee/ePold1e/e (n = 35) in C57BL/6 (Neo−); black indicates wild-type (WT; n = 37) C57BL/6; green indicates Mlh1Δ/Δ (n = 27) in C57BL/6. One month = 30.4 days. (B) Spontaneous tumor incidences. Moribund mice were euthanized and necropsied, and tumors were diagnosed by histology. *, Incidences among 32 wild-type (WT), 33 Polee/e, 36 Pold1e/e, 26 Mlh1Δ/Δ, and 34 Polee/ePold1e/e mice. †, Tumors with 15% or greater incidence in 1 or more groups. See Table S1 for details and rare tumors.