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Genetic deletion of TNFα (dbTNF−/dbTNF−) (A, n=8 mice), apocynin and TEMPOL (C, n=4 mice) partially restored impaired vasorelaxation in Leprdb. TNFα incubation impaired endothelial function in m Leprdb (A, n=6 mice) and abolished the improvement in endothelial function by resveratrol treatment in Leprdb (B, n=6 mice). *p<0.05 vs. m Leprdb; #p<0.05 vs. Leprdb.
