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Incorporation of “low fidelity” dNTPs by BF and pol α.
| dNTP | Template | kcat (min−1) |
KM (µM) |
kcat/KM (µM−1 min−1) |
|---|---|---|---|---|
| Pol α | ||||
| G | 6.4 ± 1.0 | 25 ± 11 | 0.25 | |
| 6NO2dBTP | I | 4.8 ± 0.2 | 15 ± 3 | 0.32 |
| 8-OxoG | 1.8 ± 0.2 | 7.0 ± 4.0 | 0.25 | |
| BF | ||||
| G | 20 ± 0.3 | 43 ± 2 | 0.46 | |
| 6CF3dBTP | I | 23 ± 3 | 90 ± 20 | 0.25 |
| 8-OxoG | 4.0 ± 0.4 | 130 ± 60 | 0.30 | |
