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Ligation of HLA class I molecules on ECs induces cytoskeleton rearrangement. Ligation of class I molecules by anti-HLA class I antibodies on the surface of ECs increases Rho-GTP activity, induces phosphorylation of ROK, and stimulates actin reorganization and assembly of stress fibers. RhoGTPase activation also triggers the assembly of FAK, Src and paxillin at the focal adhesions and subsequent phosphorylation of these proteins.
