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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Exp Neurol. 2009 Aug 22;220(1):171–176. doi: 10.1016/j.expneurol.2009.08.014

Figure 1.

Figure 1

Mitochondrial dysfunction occurs with age in dogs. A. Reactive oxygen species production was higher overall in aged dogs and was further increased over time. B. Age effects were seen selectively as a decrease in NADH-linked, complex I-driven respiration rate but not in complex II, III, IV, or in complex V in the presence of the mitochondrial uncoupler FCCP and pyruvate/malate (V(P/M)) or following the addition of rotenone and succinate treatment (V(S)). Bars represent group means, error bars represent standard error of the mean. * p<.05 between young and old dogs at each time point measured. A. Note that young animals showed minimal individual variability and error bars in the graph cannot be seen with the scaling of the y-axis but the standard errors were as follows: ROS at 5 min = 0.87, at 10 min = 1.7 and at 15 min = 2.73.