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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: Circ Res. 2009 Aug 20;105(7):705–712. doi: 10.1161/CIRCRESAHA.109.205310

Figure 5.

Figure 5

p53 modulates TFAM expression in skeletal muscle. A, p53 affects the basal expression of TFAM mRNA in soleus muscle but not in heart or liver, n = 5–9 each. B, p53 affects the level of TFAM protein in soleus muscle but not in heart or liver. (Note: TFAM protein in liver is undetectable at this level of sensitivity consistent with its low mtDNA content shown in Figure 6A; TFAM resolves as a single or double band in mouse skeletal muscle or heart tissue, respectively) C, Acute exercise (14 m/min for 1 h) increases TFAM mRNA expression in soleus muscle of p53+/+ mice. **P < 0.01 versus pre-exercise level; n = 3–5. D, Relative TFAM mRNA expression in soleus 12 h after acute exercise. *P < 0.05 between corresponding p53+/+ (dark) and p53−/− (light) mice; n = 6. Mean ± SEM.