Table 3.
Regression Estimates of Child 3-Year Adiposity-Related Measures on Continuous Cord Blood Leptin (per 10 ng/mL) and Adiponectin (per 10µg/mL) Exposure
| Variable | Cord Blood Leptin | Cord Blood Adiponectin | ||
|---|---|---|---|---|
| Estimate (95% CI) | P | Estimate (95% CI) | P | |
| BMI z score at 3 y of age | ||||
| M1 | −0.09 (−0.22 to 0.04) | .20 | 0.06 (−0.07 to 0.18) | .38 |
| M2 | −0.16 (−0.30 to−0.02) | .02 | 0.08 (−0.04 to 0.21) | .18 |
| M3 | −0.29 (−0.43 to−0.14) | .0001 | 0.07 (−0.06 to 0.19) | .29 |
| Weight-for-age z score at 3 y of age | ||||
| M1 | −0.03 (−0.15 to 0.10) | .67 | 0.001 (−0.12 to 0.12) | .98 |
| M2 | −0.10 (−0.23 to 0.03) | .15 | 0.03 (−0.09 to 0.15) | .63 |
| M3 | −0.28 (−0.42 to−0.14) | <.0001 | 0.002 (−0.11 to 0.12) | .98 |
| Height-for-age z score at 3 y of age | ||||
| M1 | 0.05 (−0.07 to 0.17) | .42 | −0.08 (−0.19 to 0.03) | .16 |
| M2 | −0.00 (−0.14 to 0.14) | .99 | −0.07 (−0.19 to 0.05) | .26 |
| M3 | −0.16 (−0.30 to−0.02) | .03 | −0.10 (−0.21 to 0.02) | .10 |
| Leg length at 3 y of age | ||||
| M1 | −0.20 (−0.59 to 0.19) | .30 | −0.42 (−0.79 to−0.05) | .02 |
| M2 | −0.06 (−0.41 to 0.30) | .75 | −0.09 (−0.40 to 0.22) | .57 |
| M3 | −0.40 (−0.77 to−0.04) | .03 | −0.16 (−0.46 to 0.15) | .31 |
| SS+TR | ||||
| M1 | 0.19 (−0.36 to 0.74) | .50 | 0.40 (−0.11 to 0.91) | .13 |
| M2 | −0.02 (−0.63 to 0.58) | .94 | 0.45 (−0.08 to 0.98) | .09 |
| M3 | −0.24 (−0.88 to 0.41) | .48 | 0.42 (−0.11 to 0.95) | .12 |
| SS/TR | ||||
| M1 | 0.92 (−1.03 to 2.87) | .35 | 1.83 (0.01 to 3.66) | .05 |
| M2 | −0.43 (−2.64 to 1.79) | .71 | 1.96 (0.04 to 3.88) | .05 |
| M3 | −0.22 (−2.61 to 2.17) | .86 | 2.01 (0.09 to 3.93) | .04 |
| 3-y leptin | ||||
| M1 | 0.59 (0.27 to 0.91) | .0003 | 0.20 (−0.06 to 0.47) | .14 |
| M2 | 0.59 (0.28 to 0.90) | .0002 | 0.23 (0.00 to 0.45) | .05 |
| M3 | 0.58 (0.25 to 0.92) | .001 | 0.20 (−0.03 to 0.43) | .08 |
| 3-y adiponectin | ||||
| M1 | −1.15 (−2.26 to−0.03) | .04 | 0.65 (−0.26 to 1.56) | .16 |
| M2 | −0.91 (−2.22 to 0.41) | .18 | 0.61 (−0.36 to 1.57) | .22 |
| M3 | −1.38 (−2.81 to 0.05) | .06 | 0.55 (−0.42 to 1.52) | .27 |
M1 was unadjusted. M2 was adjusted for maternal education, prepregnancy BMI, gestational weight gain and duration of gestation; paternal BMI; and child age, gender, race/ethnicity, and breastfeeding duration. SS/TR outcome was additionally adjusted for BMI z score at 3 years of age. M3 was M2 plus BW/GA z score.